Factor VIII

Factor VIII is a blood clotting protein that plays a crucial role in the coagulation process. It is encoded by the F8 gene and is produced in the liver's sinusoidal cells and endothelial cells throughout the body. Defects in this gene result in hemophilia A, an X-linked bleeding disorder. The active form of factor VIII, also known as factor VIIIa, interacts with factor IX to form a complex that converts factor X to the activated form Xa, which ultimately leads to the formation of a blood clot. Factor VIII is also available as a medication that is on the WHO Model List of Essential Medicines, making it a critical component in the treatment of hemophilia A.learn more on wikipedia