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  5. Nobel Prize in Medicine awarded to Victor Ambros and Gary Ruvkun for discovery of microRNA

Nobel Prize in Medicine awarded to Victor Ambros and Gary Ruvkun for discovery of microRNA

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Victor Ambros and Gary Ruvkun, US scientists, were awarded the 2024 Nobel Prize in Medicine for the discovery of microRNA, a new class of molecules that regulate gene activity in cells. The discovery is crucial for multicellular organisms, including humans, and has the potential to help develop drugs to switch off diseases like cancer or diabetes. The Nobel Assembly of Sweden's Karolinska Institute medical university praised the discovery, stating that it revealed a new principle of gene regulation essential for multicellular organisms. The researchers conducted their studies at Harvard University, and their work explains how complex life emerged on Earth and how the human body is composed of various tissues.

  1. Karolinska Institute
    1. Their groundbreaking discovery revealed a completely new principle of gene regulation that turned out to be essential for multicellular organisms, including humans.
  2. SE
    Thomas Perlmann
    Nobel Foundation
    1. It took a long time before he came to the phone and sounded very tired, but he quite rapidly was quite excited and happy, when he understood what it was all about.
  3. SE
    Gunilla Karlsson Hedestam
    Nobel Foundation
    1. This year's prize is definitely a physiology prize.
  4. FR
    Marie-Anne Félix
    Ecole normale supérieure
    1. For a long time, it was thought that gene activity was essentially controlled during the transcription stage when messenger RNA is produced from the DNA sequence of genes.
  5. GB
    Claire Fletcher
    Imperial College London
    1. MicroRNA alters how genes in the cell work.
    2. We can take a microRNA that we know alters the activity of that gene and we can deliver that particular microRNA to cancer cells to stop that mutated gene from having its effect.
    3. If we can intervene at the microRNA level, it opens up a whole new way of us developing medicines and us controlling the activity of genes whose levels might be altered in diseases.
    4. If we take the example of cancer, we'll have a particular gene working overtime, it might be mutated and working in overdrive.
    5. The majority of therapies we have at the moment are targeting proteins in cells.
  6. SE
    Olle Kämpe
    Karolinska Institute
    1. At this point they had discovered a novel and unexpected mechanism of gene regulation — microRNA.
    2. And each mRNA is regulated by many distinct microRNAs, creating a robust system for gene regulation.
    3. MicroRNAs are important for our understanding of embryological development, normal cell physiology and diseases such as cancer. As an example, tumors often perturb microRNA networks to grow.
    4. The seminal discovery of microRNA has introduced a new and unexpected mechanism of gene regulation.

sources

  1. 1.Al Jazeera
  2. 2.The Japan Times
  3. 3.France 24
  4. 4.DW News
  5. 5.BBC
  6. 6.ABC News (Australia)
  7. 7.The Times of India
  8. 8.CGTN
  9. 9.The New York Times
  10. 10.The Korea Herald
  11. 11.Le Monde
  12. 12.Reuters

perspectives

  1. 1.Biology
  2. 2.Nobel Prize

countries

  1. 1.HungaryHU
  2. 2.IndiaIN
  3. 3.NorwayNO
  4. 4.SwedenSE
  5. 5.United StatesUS

organizations

  1. 1.Nobel FoundationSE
  2. 2.Massachusetts General Hospital
  3. 3.Harvard Medical School
  4. 4.Karolinska Institute
  5. 5.Harvard UniversityUS
  6. 6.Ecole normale supérieure
  7. 7.University of Massachusetts Medical School
  8. 8.Nanocrystals Technology Inc
  9. 9.Royal Swedish Academy of SciencesSE
  10. 10.Dublin City University
  11. 11.French National Center for Scientific Research
  12. 12.Imperial College London

persons

  1. 1.Gary Ruvkun
  2. 2.Satoshi Omura
  3. 3.Alfred Nobel
  4. 4.Katalin Kariko
  5. 5.Drew Weissman
  6. 6.Svante Pääbo
  7. 7.Victor Ambros
  8. 8.Robert Horvitz
  9. 9.Thomas PerlmannSE
  10. 10.Alexander Fleming
  11. 11.Har Gobind Khorana
  12. 12.Ivan Pavlov

technicals

  1. 1.Nobel Prize
  2. 2.Nobel Peace Price
  3. 3.2023 Nobel Prize in Physiology or Medicine
  4. 4.Sveriges Riksbank Prize in Economic Sciences
  5. 5.Nobel Prize in Medicine
  6. 6.World War I