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  5. Man Exposed to Over 200 Snakebites to Aid in Development of Antivenom

Man Exposed to Over 200 Snakebites to Aid in Development of Antivenom

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Tim Friede, a man from Wisconsin, has been exposed to snake venom hundreds of times over the course of decades, starting from his childhood when he hunted garter snakes. He has injected venom from the world's most deadly snakes into his body, including snakes such as the inland taipan, the eastern brown snake, and the saw-scaled viper. His body's immune response to the venom has resulted in the production of antibodies that are now being used to create a broadly effective antivenom.

  1. US
    Jacob Glanville
    Centivax
    1. And so we added that in and that's when we suddenly saw this coherent protection that was happening across this large panel.
    2. There's this emerging appreciation that sometimes living systems … can give rise to superior therapeutic properties.
    3. And we found the ultra-broad antibody that had this very remarkable ability to go bind right on the conserved site that the neurotoxin uses to cause paralysis.
    4. And some additional species were suddenly covered, some completely and some partially.
  2. AU
    Timothy Jackson
    University of Melbourne
    1. They're probably feeling pretty crappy for a lot of the time because their immune system is fighting an active pathogen.
  3. GB
    Stuart Ainsworth
    University of Liverpool
    1. So they might lose a limb, they might lose function in a limb, they might end up having to have huge surgeries, skin grafts, that kind of thing.
  4. US
    Tim Friede
    1. It's like a bee sting times a thousand. I mean, you can have levels of anxiety that goes through the roof.
  5. US
    Peter Kwong
    Columbia University
    1. The current technology hasn't really changed in over 100 years.
    2. It got really exciting when we started seeing mice live.
    3. Whereas with [this new] approach … you can use all the tools of modern antibody therapy.
    4. A really smart editor said, 'Look, antibodies are wonderful, but I think we could actually go further,'

sources

  1. 1.ABC News (Australia)
  2. 2.NPR
  3. 3.CTV News

perspectives

  1. 1.Healthcare
  2. 2.Biology
  3. 3.Snake

countries

  1. 1.AustraliaAU
  2. 2.IndiaIN
  3. 3.Papua New GuineaPG
  4. 4.United StatesUS

organizations

  1. 1.Centivax
  2. 2.World Health Organization
  3. 3.US Department of Agriculture
  4. 4.Australian Venom Research Unit
  5. 5.Columbia UniversityUS
  6. 6.University of Liverpool
  7. 7.University of Melbourne

persons

  1. 1.Tim FriedeUS
  2. 2.Jacob GlanvilleUS
  3. 3.Ari Daniel Tim Friede
  4. 4.Christina Zdenek
  5. 5.David Williams
  6. 6.Timothy JacksonAU

technicals

  1. 1.95Mat5
Man Exposed to Over 200 Snakebites to Aid in Development of Antivenom