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First Human Death from Bird Flu Reported in the United States

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A patient over the age of 65 with underlying medical conditions has died after being hospitalized in the United States. The death was caused by the H5N1 bird flu virus, the first such case in the country. A genetic analysis suggested that the virus had mutated inside the patient. The patient was hospitalized in December with severe respiratory symptoms after being exposed to a combination of wild birds. This is the first recorded death from bird flu in the US and there have been no other detected cases in the state. Across the US, a total of 66 people have been infected with the virus.

    1. These changes would be more concerning if found in animal hosts or in early stages of infection (eg, within a few days of symptom onset), when these changes might be more likely to facilitate spread to close contacts.
    1. While the current public health risk for the general public remains low, people who work with birds, poultry or cows, or have recreational exposure to them, are at higher risk.
    2. LDH's extensive public health investigation has identified no additional H5N1 cases nor evidence of person-to-person transmission. This patient remains the only human case of H5N1 in Louisiana.
    1. We've been studying the family tree of this virus for 25 odd years, and this is probably the nastiest form of the virus that we've seen. So the fact that it finally did cause a fatal infection here is tragic but not surprising.
    1. The evolution of the virus is concerning but highlights how we need to prevent each possible spillover infection to reduce the risk of onward transmission to others.
    1. Is this an indication that we may be closer to seeing a readily transmitted virus between people? No.
    2. Right now, this is a key that sits in the lock, but it doesn't open the door.
First Human Death from Bird Flu Reported in the United States